Turkesterone Powder CAS 41451-87-0

Turkesterone powder possesses a polyhydroxylated structure with a cyclopentanoperhydrophenanthrene skeleton, typically consisting of 27 - 30 carbon atoms and a -oriented side chain at C17, resembling cholesterol-derived steroids.However, unlike anabolic-androgenic steroid, turkesterone does not bind to the androgen receptor. Instead, it is hypothesized to exert anabolic effects through the activation of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, which regulates protein synthesis, cellular growth, and muscle hypertrophy.Additionally, turkesterone has been implicated in promoting nitrogen retention, enhancing mitochondrial biogenesis of organelles, and modulating lipid and carbohydrate metabolism, contributing to improved physical performance and recovery.Its bioactivity extends beyond muscle anabolism, demonstrating adaptogenic, antioxidant, and neuroprotective properties, making it a promising candidate for therapeutic applications in stress resilience, neurodegeneration, and metabolic disorders.

Dew grass (2.5kg) was extracted by heating and refluxing with 75% solvent, and the solvent was recovered to obtain a concentrated solution. Extract with ethyl acetate and n-butanol; Take ethyl acetate extract and perform Al2O3 (neutral) column chromatography with gradient elution. The eluted portion is recrystallized from ethyl acetate methanol to obtain compound 3 (200mg); Compound 1 (10mg) was obtained by preparative thin-layer chromatography with a 3:1 elution ratio; (5mg) was separated by preparative high-performance liquid chromatography (ODS, methanol/water=31:69242nm detection) using methanol elution.