Idra-21 Kognitiv kukunAMPA retseptorlarining ijobiy allosterik regulyatori va benzotiadiazol hosilasidir. Bu chiral molekula bo'lib, unda ( plus ) - IDRA-21 faol shakldir.
Hayvonlar tajribasida IDRA-21 qanday harakat qildi?
Hayvonlarda aqlni rivojlantirishni o'rganishda,IDRA-21 kukunio'rganish va xotira qobiliyatini sezilarli darajada yaxshiladi. Alprazolam yoki skopolamindan uzoq muddat foydalanish natijasida kelib chiqqan kognitiv nuqsonlarni bartaraf etishda u aniratsetamga qaraganda 10-30 baravar kuchliroqdir. Eng hayratlanarlisi, uning dori almashinuvi vaqti: bir marta qabul qilinganidan keyin 48 soatgacha davom etadigan barqaror ta'sir ko'rsatishi o'rganilgan. Tadqiqotchilarning ta'kidlashicha, bu ta'sir mexanizmi, ehtimol, miya sinapslari o'rtasida uzoq muddatli yaxshilanishni rag'batlantirish orqali bo'lishi mumkin.
Kognitiv kuchaytiruvchi dori-darmonlarni izlash jarayoni qanday? Qanday bo'lganIDRA-21tug'ilganmi?
In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.