Ribavirin, a guanosine and hypoxanthine nucleoside analogue, is a broad-spectrum antiviral drug, which has a good inhibitory effect on a variety of DNA and RNA viruses. It has the characteristics of many action sites, difficult drug resistance, high curative effect, low toxicity and little side effects, and has been used to treat many viruses. It is clinically used to treat hepatitis C virus, respiratory syncytial virus and Lassa fever virus infection.
is a white powder, which is easily soluble in water, slightly soluble in ethanol (96%), slightly soluble or extremely slightly soluble in dichloromethane. It shows polymorphism .
| 36791-04-5 | |
| C8H12N4O5 | |
| 244.21 | |
| 636-825-3 | |
| 174-176℃ | |
| 1.4287 (rough estimate) | |
| White to off-white | |
| 2-8℃ | |
| Soluble in water and slightly soluble in ethanol (96%) |
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Off-white or white powder |
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-33.5℃~ -37.0℃ |
-36.5℃ |
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4.0~ 6.5 |
4.5 |
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<=0.5% |
4.5 |
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<=0.25% |
0.0% |
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<=0.001% |
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Individual peak <= 0.25%
Total <= 1.0 % |
1. 0.04% 2. 0.01% Total: 0.1% |
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Methanol <= 0.3 % Ethanol <=0.5 % |
0.012% |
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98.9%~101.5% |
99.9% |
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| USP36. | ||
1. Ribavirin is phosphorylated in red blood cells to produce ribavirin monophosphate, diphosphate and triphosphate. Among them, ribavirin monophosphate is a strong inhibitor of inosine monophosphate dehydrogenase, which can inhibit the synthesis of cellular guanosine monophosphate, reduce the triphosphatation of cellular guanosine monophosphate and block the synthesis of viral nucleic acid.
2. Triazole nucleoside triphosphate inhibits influenza virus RNA polymerase, and interferes with virus replication.
3. Triazole nucleoside triphosphate inhibits the synthesis and transcriptase at the 5' end of viral mRNA, thus inhibiting the synthesis of DNA and RNA. It can inhibit a variety of viruses (including DNA virus and RNA virus). can be used for preventing and treating influenza, adenovirus pneumonia, hepatitis A, herpes and measles, and is also effective for epidemic hemorrhagic fever.
4. It is mainly excreted by urine in its original form, and there are also a small amount of glycosyltriazole nucleoside metabolites, and a small amount is excreted from feces.
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reliable strength supply, high quality and stable storage, worry-free supply and timely delivery after sale.
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3-7 days |
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Suitable for under 50kg. |
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7-15 days |
Suitable for more than 50kg. |
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15-60 days |
Suitable for more than 500kg. |
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It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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